PYROXD1

Across TCGA cell cohorts, PYROXD1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PYROXD1-associated genes across cancer lineages are DCANP1, KRTAP11-1, and C1QTNF7. Each is linked with PYROXD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYROXD1-to-partner and partner-to-PYROXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCANP1 grouped by PYROXD1-low versus PYROXD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYROXD1→partner) and Y-score (partner→PYROXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DCANP1 →	+0.011	+3.347	<.001	.005	3	2
OVARY	KRTAP11-1 →	+0.139	+5.807	<.001	.001	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.081	+4.108	.001	.008	3	1
LARGE_INTESTINE	OR4F3 →	+0.066	+3.836	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

DCANP1 by PYROXD1 expression — LARGE_INTESTINE

Explore this box plot interactively →