PYM1

Across TCGA patient cohorts, PYM1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYM1-associated genes across cancer lineages are Ku80, Notch1, and PDCD4. Each is linked with PYM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYM1-to-partner and partner-to-PYM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by PYM1-low versus PYM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYM1→partner) and Y-score (partner→PYM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.309	+3.009	.009	.019	3	1
UCEC	Notch1 →	+0.240	+3.013	<.001	.018	3	1
UCEC	PDCD4 →	-0.668	-2.321	.004	.035	3	1
UCEC	PTEN →	-0.401	-2.321	.044	.035	3	1
UCEC	STAT3_pY705 →	-0.545	-2.321	<.001	.035	3	1
UCEC	ATM →	-0.716	-2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Ku80 by PYM1 expression — UCEC

Explore this box plot interactively →