PYHIN1

Across TCGA pan-cancer cohorts, PYHIN1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PYHIN1 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PYHIN1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PYHIN1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where PYHIN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.799	0.256	.006	22	view →
LUAD	DFS	Tertile	All	0.812	0.478	.001	17	view →
CCRCC	OS	Tertile	II,III,IV	1.000	0.506	.004	8	view →
HNSC	OS	Median	III,IV	0.543	0.813	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PYHIN1–PDAC (DFS)

Open the PDAC breakdown →