PYHIN1

Across TCGA patient cohorts, PYHIN1 mutation is significantly associated with the RNA expression of many other genes, with 5,808 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYHIN1-associated genes across cancer lineages are UBE2T, VRK1, and COX15. Each is linked with PYHIN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PYHIN1-to-partner and partner-to-PYHIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2T grouped by PYHIN1-low versus PYHIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYHIN1→partner) and Y-score (partner→PYHIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBE2T →	+0.730	+2.457	<.001	<.001	3	5
UCEC	VRK1 →	+0.520	+1.709	<.001	<.001	3	5
SKCM	COX15 →	+0.425	+1.642	<.001	.005	3	4
STAD	SUPV3L1 →	+0.542	+3.371	.001	.004	3	4
UCEC	CHAF1B →	+0.725	+3.392	<.001	<.001	3	4
UCEC	PKN3 →	+0.839	+2.425	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,808 associations by consensus.

UBE2T by PYHIN1 expression — UCEC

Explore this box plot interactively →