PYHIN1

Across TCGA cell cohorts, PYHIN1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PYHIN1-associated genes across cancer lineages are ZNRF4, MTNR1B, and OR10W1. Each is linked with PYHIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYHIN1-to-partner and partner-to-PYHIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNRF4 grouped by PYHIN1-low versus PYHIN1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYHIN1→partner) and Y-score (partner→PYHIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNRF4 →	+0.022	+4.781	<.001	.003	3	1
BREAST	MTNR1B →	+0.068	+4.199	<.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.013	+3.977	<.001	<.001	3	1
LARGE_INTESTINE	ACSM6 →	+0.016	+3.000	.005	.005	3	1
BLOOD_Leukemia	NKX2-6 →	+0.663	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ZNRF4 by PYHIN1 expression — BREAST

Explore this box plot interactively →