PYGO2

Across TCGA patient cohorts, PYGO2 RNA expression is significantly associated with the RNA expression of many other genes, with 19,963 significant associations in total. ACC shows the largest number of these associations.

The most reproducible PYGO2-associated genes across cancer lineages are SH3BP5L, DENND4B, and SMG5. Each is linked with PYGO2 in more than 33 cancer types. Because this analysis shows association rather than direction, both PYGO2-to-partner and partner-to-PYGO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PYGO2 versus SH3BP5L in ACC, with a Pearson correlation of 0.75.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO2→partner) and Y-score (partner→PYGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	SH3BP5L →	+1.169	+0.987	<.001	<.001	3	34
ACC	DENND4B →	+1.308	+1.126	<.001	<.001	3	34
ACC	SMG5 →	+1.351	+1.095	<.001	<.001	3	34
ACC	IPO9 →	+1.155	+1.177	<.001	<.001	3	34
SCLC	PRRC2A →	+1.355	+0.449	<.001	<.001	3	34
ACC	CHERP →	+1.260	+1.072	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,963 associations by consensus.

PYGO2 vs SH3BP5L — ACC

Explore this scatter interactively →