PYGO2

Across TCGA patient cohorts, PYGO2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,383 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PYGO2-associated genes across cancer lineages are JMJD4, HDGF, and VPS72. Each is linked with PYGO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PYGO2-to-partner and partner-to-PYGO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PYGO2 versus JMJD4 in LUAD, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO2→partner) and Y-score (partner→PYGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	JMJD4 →	+0.453	+0.195	<.001	<.001	3	3
LUAD	HDGF →	+0.562	+0.210	<.001	<.001	3	3
BRCA	VPS72 →	+0.465	+0.270	<.001	<.001	3	3
LUAD	TIGD2 →	+0.522	+0.162	<.001	.002	3	3
BRCA	NOP56 →	+0.370	+0.279	.008	.002	3	2
LUAD	SEC61G →	+0.489	+0.142	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,383 associations by consensus.

PYGO2 vs JMJD4 — LUAD

Explore this scatter interactively →