PYGO2

Across TCGA patient cohorts, PYGO2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYGO2-associated genes across cancer lineages are Fibronectin, Ku80, and Annexin-1. Each is linked with PYGO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYGO2-to-partner and partner-to-PYGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by PYGO2-low versus PYGO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO2→partner) and Y-score (partner→PYGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.341	-2.990	.039	.036	3	1
UCEC	Ku80 →	+0.303	+2.820	.010	.035	3	1
UCEC	Annexin-1 →	+0.682	+3.019	.009	.019	3	1
UCEC	Caspase-8 →	-0.302	-3.169	.016	.019	2	1
UCEC	4E-BP1 →	+0.450	+2.321	<.001	.035	1	2
UCEC	53BP1 →	+0.441	+3.169	.010	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Fibronectin by PYGO2 expression — UCEC

Explore this box plot interactively →