PYGO2

Across TCGA cell cohorts, PYGO2 RNA expression is significantly associated with the RNA expression of many other genes, with 12,976 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PYGO2-associated genes across cancer lineages are USP21, POGZ, and ASH1L. Each is linked with PYGO2 in more than 19 cancer types. Because this analysis shows association rather than direction, both PYGO2-to-partner and partner-to-PYGO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PYGO2 versus USP21 in LUNG_NSCLC_LUSC, with a Pearson correlation of 0.78.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO2→partner) and Y-score (partner→PYGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	USP21 →	+1.438	+1.068	<.001	<.001	3	20
BLOOD_Myeloma	POGZ →	+1.284	+0.682	<.001	.001	3	20
URINARY_TRACT	ASH1L →	+1.044	+1.020	<.001	<.001	3	20
LIVER	GON4L →	+1.091	+0.811	.001	.001	3	20
STOMACH	CLK2 →	+1.285	+0.968	<.001	<.001	3	19
URINARY_TRACT	SMG5 →	+1.323	+1.216	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,976 associations by consensus.

PYGO2 vs USP21 — LUNG_NSCLC_LUSC

Explore this scatter interactively →