PYGO2

Across TCGA cell cohorts, PYGO2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,216 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PYGO2-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Regulation of termination of RNA polymerase II transcription, and Positive regulation of double-strand break repair via homologous recombination. Each is linked with PYGO2 in more than 14 cancer types. Because this analysis shows association rather than direction, both PYGO2-to-partner and partner-to-PYGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by PYGO2-low versus PYGO2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO2→partner) and Y-score (partner→PYGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.085	+1.120	<.001	<.001	3	15
BLOOD_Myeloma	Regulation of termination of RNA polymerase II transcription →	+0.110	+0.562	<.001	.002	3	14
BONE	Positive regulation of double-strand break repair via homologous recombination →	+0.083	+0.686	.001	.005	3	14
LUNG_SCLC	Regulation of nucleotide-excision repair →	+0.115	+0.565	<.001	.001	2	15
BLOOD_Myeloma	Regulation of termination of DNA-templated transcription →	+0.110	+0.562	<.001	.002	3	14
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.066	+0.829	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,216 associations by consensus.

Positive regulation of double-strand break repair by PYGO2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →