PYGO2

Across TCGA cell cohorts, PYGO2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PYGO2-associated genes across cancer lineages are MRGPRG, SLCO1C1, and XKR3. Each is linked with PYGO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYGO2-to-partner and partner-to-PYGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRG grouped by PYGO2-low versus PYGO2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO2→partner) and Y-score (partner→PYGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MRGPRG →	+0.022	+3.544	<.001	.009	3	2
LARGE_INTESTINE	SLCO1C1 →	+0.383	+3.035	<.001	.003	3	1
LARGE_INTESTINE	XKR3 →	+0.029	+3.378	.002	.001	3	1
LARGE_INTESTINE	PROP1 →	+0.016	+2.791	.006	.005	3	1
LARGE_INTESTINE	FCER1A →	+0.184	+3.285	.001	.007	3	1
LARGE_INTESTINE	OR13G1 →	+0.016	+3.678	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MRGPRG by PYGO2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →