PYDC2

Across TCGA pan-cancer cohorts, PYDC2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PYDC2 data layer compared with 11 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PYDC2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PYDC2 expression acts as an unfavorable survival marker.

COAD, UCEC, and STAD are the cancer types where PYDC2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.125	0.801	<.001	33	view →
UCEC	OS	Median	All	0.615	0.873	.008	30	view →
STAD	OS	Median	II,III,IV	0.183	0.677	.004	24	view →
SKCM	DFS	Median	All	0.318	0.735	.001	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PYDC2–COAD (OS)

Open the COAD breakdown →