PYDC2

Across TCGA patient cohorts, PYDC2 mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PYDC2-associated genes across cancer lineages are MIR1298, MDH1P2, and LINC02629. Each is linked with PYDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYDC2-to-partner and partner-to-PYDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1298 grouped by PYDC2-low versus PYDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYDC2→partner) and Y-score (partner→PYDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR1298 →	+0.373	+8.066	<.001	.007	3	2
LUAD	MDH1P2 →	+0.063	+4.279	<.001	.001	3	2
LUAD	LINC02629 →	+0.101	+3.990	.001	.003	3	2
LUAD	HMGN2P22 →	+0.454	+4.513	<.001	<.001	3	2
SKCM	SIGLEC31P →	+0.056	+3.180	.003	.004	3	2
UCEC	IGHD5-5 →	+1.131	+8.066	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

MIR1298 by PYDC2 expression — UCEC

Explore this box plot interactively →