PYDC1

Across TCGA pan-cancer cohorts, PYDC1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PYDC1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PYDC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PYDC1 is over-expressed in tumor.

THCA, BRCA, and LUSC are the cancer types where PYDC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PYDC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	+0.299	<.001	8	view →
BRCA	All	All	+1.779	<.001	6	view →
LUSC	All	All	+0.633	<.001	4	view →
LIHC	All	II,III,IV	+0.508	.006	4	view →
COAD	All	All	+0.189	.006	3	view →
KIRC	All	All	+0.187	.010	3	view →
LUAD	All	All	+0.116	.011	2	view →
CHOL	Male	All	+0.135	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PYDC1–THCA

Open the THCA breakdown →