PYCR2

Across TCGA patient cohorts, PYCR2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYCR2-associated genes across cancer lineages are p62 Lck ligand, Stathmin, and eIF4E. Each is linked with PYCR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYCR2-to-partner and partner-to-PYCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PYCR2-low versus PYCR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYCR2→partner) and Y-score (partner→PYCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.513	+2.817	.006	.036	3	1
UCEC	Stathmin →	+0.160	+3.000	.043	.037	3	1
UCEC	eIF4E →	+0.240	+3.000	.049	.037	1	1
UCEC	FoxM1 →	+0.448	+3.000	.002	.037	1	1
UCEC	mTOR_pS2448 →	-0.193	-3.000	.025	.037	1	1
UCEC	PDCD4 →	-0.786	-3.000	.003	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

p62 Lck ligand by PYCR2 expression — UCEC

Explore this box plot interactively →