PYCR2

Across TCGA cell cohorts, PYCR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PYCR2-associated GO terms across cancer lineages are Regulation of tRNA metabolic process, Pre-mRNA catabolic process, and Negative regulation of RNA splicing. Each is linked with PYCR2 in more than 11 cancer types. Because this analysis shows association rather than direction, both PYCR2-to-partner and partner-to-PYCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of tRNA metabolic process grouped by PYCR2-low versus PYCR2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PYCR2→partner) and Y-score (partner→PYCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of tRNA metabolic process →	+0.139	+0.786	.001	<.001	3	12
BONE	Pre-mRNA catabolic process →	+0.196	+0.718	.005	.002	3	11
LARGE_INTESTINE	Negative regulation of RNA splicing →	+0.081	+0.581	<.001	.004	3	11
LARGE_INTESTINE	Nucleic acid transport →	+0.087	+0.757	<.001	<.001	3	11
LARGE_INTESTINE	RNA transport →	+0.087	+0.757	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.165	+0.997	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,395 associations by consensus.

Regulation of tRNA metabolic process by PYCR2 expression — BONE

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