PYCR1

Across TCGA patient cohorts, PYCR1 mutation is significantly associated with the RNA expression of many other genes, with 1,311 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYCR1-associated genes across cancer lineages are RN7SL814P, ATG3P1, and MIR558. Each is linked with PYCR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYCR1-to-partner and partner-to-PYCR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL814P grouped by PYCR1-low versus PYCR1-high in SARC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYCR1→partner) and Y-score (partner→PYCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	RN7SL814P →	+0.215	+6.649	<.001	<.001	3	2
HNSC	ATG3P1 →	+0.050	+5.736	<.001	.003	3	2
BLCA	MIR558 →	+0.479	+4.450	<.001	.002	3	2
LUSC	ABCD1P3 →	+0.071	+4.625	<.001	.008	3	2
UCEC	TRGJP2 →	+0.643	+2.374	<.001	.001	3	2
UCEC	RNA5SP146 →	+0.200	+2.261	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,311 associations by consensus.

RN7SL814P by PYCR1 expression — SARC

Explore this box plot interactively →