PYCR1

Across TCGA cell cohorts, PYCR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,842 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PYCR1-associated GO terms across cancer lineages are Alpha-amino acid biosynthetic process, Transsulfuration, and Homocysteine metabolic process. Each is linked with PYCR1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PYCR1-to-partner and partner-to-PYCR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Alpha-amino acid biosynthetic process grouped by PYCR1-low versus PYCR1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PYCR1→partner) and Y-score (partner→PYCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Alpha-amino acid biosynthetic process →	+0.106	+1.165	<.001	<.001	2	13
OESOPHAGUS	Transsulfuration →	+0.333	+2.048	<.001	<.001	3	12
LARGE_INTESTINE	Homocysteine metabolic process →	+0.111	+0.946	<.001	<.001	3	12
BONE	Proteinogenic amino acid biosynthetic process →	+0.132	+0.810	<.001	.002	3	11
BLOOD_Leukemia	Hydrogen sulfide biosynthetic process →	+0.296	+1.126	<.001	.001	3	11
BLOOD_Leukemia	Amino acid biosynthetic process →	+0.112	+1.875	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,842 associations by consensus.

Alpha-amino acid biosynthetic process by PYCR1 expression — SKIN

Explore this box plot interactively →