PYCR1

Across TCGA cell cohorts, PYCR1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PYCR1-associated genes across cancer lineages are CABP2, USP17L13, and USP17L17. Each is linked with PYCR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYCR1-to-partner and partner-to-PYCR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CABP2 grouped by PYCR1-low versus PYCR1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYCR1→partner) and Y-score (partner→PYCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CABP2 →	+0.040	+5.029	.006	.006	3	1
LUNG_SCLC	USP17L13 →	+0.013	+5.029	<.001	.006	3	1
LUNG_SCLC	USP17L17 →	+0.013	+5.029	<.001	.006	3	1
BLOOD_Leukemia	WFDC11 →	+0.030	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR1G1 →	+0.080	+4.705	<.001	.003	3	1
BLOOD_Leukemia	OR1D4 →	+0.046	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CABP2 by PYCR1 expression — LUNG_SCLC

Explore this box plot interactively →