PYCARD

Across TCGA patient cohorts, PYCARD protein abundance is significantly associated with the protein abundance of many other proteins, with 21,312 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PYCARD-associated proteins across cancer lineages are LCP1_S257, IFI35, and NMI. Each is linked with PYCARD in more than 8 cancer types. Because this analysis shows association rather than direction, both PYCARD-to-partner and partner-to-PYCARD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PYCARD versus LCP1_S257 in GBM, with a Pearson correlation of 0.55.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PYCARD→partner) and Y-score (partner→PYCARD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LCP1_S257 →	+0.917	+0.569	<.001	<.001	3	9
HNSC	IFI35 →	+0.629	+0.577	<.001	<.001	3	9
HNSC	NMI →	+0.620	+0.617	<.001	<.001	3	9
GBM	MAPK14 →	+0.247	+0.528	<.001	<.001	3	8
GBM	RCSD1 →	+0.684	+0.675	<.001	<.001	3	8
GBM	SKAP2 →	+0.867	+0.611	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,312 associations by consensus.

PYCARD vs LCP1_S257 — GBM

Explore this scatter interactively →