PXMP2

Across TCGA pan-cancer cohorts, PXMP2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PXMP2 data layer compared with 20 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PXMP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PXMP2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where PXMP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.759	1.000	.008	24	view →
LUAD	OS	Median	All	1.000	0.914	.010	15	view →
CCRCC	OS	Tertile	III,IV	0.928	0.670	.011	11	view →
LSCC	OS	Quartile	II,III,IV	0.903	0.568	.029	5	view →
UCEC	DFS	Median	All	0.766	0.971	.035	4	view →
GBM	OS	Median	All	0.600	0.268	.020	2	view →
PDAC	DFS	Quartile	All	0.316	0.670	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PXMP2–HNSC (DFS)

Open the HNSC breakdown →