PXK

Across TCGA pan-cancer cohorts, PXK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PXK data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PXK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PXK expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where PXK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.456	0.936	.003	28	view →
LUAD	DFS	Quartile	All	0.849	0.376	<.001	16	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	7	view →
LSCC	DFS	Tertile	II,III,IV	0.561	0.901	.019	6	view →
PDAC	DFS	Quartile	II,III,IV	0.631	0.805	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PXK–UCEC (DFS)

Open the UCEC breakdown →