PXK

Across TCGA patient cohorts, PXK mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PXK-associated genes across cancer lineages are PDK1_pS241, Caspase-8, and 14-3-3_beta. Each is linked with PXK in more than 1 cancer types. Because this analysis shows association rather than direction, both PXK-to-partner and partner-to-PXK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by PXK-low versus PXK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PXK→partner) and Y-score (partner→PXK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1_pS241 →	+0.177	+3.584	.014	.002	3	2
UCEC	Caspase-8 →	-0.231	-2.295	.030	.033	3	2
UCEC	14-3-3_beta →	-0.085	-2.973	.046	.035	3	1
UCEC	eIF4E →	+0.189	+2.222	.034	.011	3	1
UCEC	JNK2 →	+0.194	+1.700	.021	.044	3	1
UCEC	MEK1 →	+0.484	+2.906	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PDK1_pS241 by PXK expression — UCEC

Explore this box plot interactively →