PXK

Across TCGA cell cohorts, PXK RNA expression is significantly associated with the go_rna of many other GO terms, with 5,211 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PXK-associated GO terms across cancer lineages are Positive regulation of pinocytosis, Neuropilin signaling pathway, and Negative regulation of hippo signaling. Each is linked with PXK in more than 12 cancer types. Because this analysis shows association rather than direction, both PXK-to-partner and partner-to-PXK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of pinocytosis grouped by PXK-low versus PXK-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PXK→partner) and Y-score (partner→PXK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of pinocytosis →	+0.112	+1.394	<.001	<.001	3	13
SOFT_TISSUE	Neuropilin signaling pathway →	+0.168	+1.054	.002	.004	3	10
LUNG_NSCLC_LUSC	Negative regulation of hippo signaling →	+0.078	+1.504	.001	<.001	3	10
BONE	Piecemeal microautophagy of the nucleus →	+0.075	+1.340	<.001	<.001	3	9
BONE	Vesicle cargo loading →	+0.175	+1.679	<.001	<.001	3	9
BONE	TRAM-dependent toll-like receptor signaling pathway →	+1.109	+1.280	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,211 associations by consensus.

Positive regulation of pinocytosis by PXK expression — SOFT_TISSUE

Explore this box plot interactively →