PXK

Across TCGA cell cohorts, PXK mutation is significantly associated with the RNA expression of many other genes, with 301 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PXK-associated genes across cancer lineages are OR52K1, SPATS1, and DEFB133. Each is linked with PXK in more than 1 cancer types. Because this analysis shows association rather than direction, both PXK-to-partner and partner-to-PXK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52K1 grouped by PXK-low versus PXK-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PXK→partner) and Y-score (partner→PXK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR52K1 →	+0.016	+5.169	<.001	.001	3	1
BLOOD_Lymphoma	SPATS1 →	+0.939	+4.714	<.001	.002	3	1
CNS	DEFB133 →	+0.028	+4.772	<.001	.002	3	1
SKIN	TSHB →	+0.164	+5.022	<.001	.002	3	1
SKIN	CBLL2 →	+0.012	+4.415	<.001	.007	3	1
SKIN	OR10S1 →	+0.099	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 301 associations by consensus.

OR52K1 by PXK expression — BLOOD_Lymphoma

Explore this box plot interactively →