PXDN

Across TCGA pan-cancer cohorts, PXDN Mutation is linked to patient survival in 14 of 34 cancer types, making it a survival-associated PXDN data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PXDN Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PXDN expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and ESCA are the cancer types where PXDN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.915	0.587	.001	26	view →
HNSC	DFS	Median	All	1.000	0.339	.017	17	view →
ESCA	OS	Median	All	0.470	0.906	.020	12	view →
SCLC	OS	Median	All	0.301	0.716	.004	12	view →
LIHC	DFS	Median	III,IV	1.000	0.130	.024	7	view →
PCPG	DFS	Median	All	0.063	0.924	<.001	6	view →
LUSC	DFS	Median	II,III,IV	0.135	0.663	.015	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
LUAD	OS	Median	III,IV	0.299	0.686	.027	6	view →
COAD	OS	Median	II,III,IV	0.509	0.796	.014	4	view →
LGG	DFS	Median	All	0.241	0.731	.002	3	view →
READ	DFS	Median	II,III,IV	1.000	0.438	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

PXDN–UCEC (DFS)

Open the UCEC breakdown →