PWWP3A

Across TCGA pan-cancer cohorts, PWWP3A Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PWWP3A data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PWWP3A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PWWP3A expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

LUSC, OV, and READ are the cancer types where PWWP3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.159	0.678	<.001	48	view →
OV	OS	Median	All	0.244	0.690	.006	18	view →
READ	OS	Median	All	0.183	0.828	<.001	12	view →
LUAD	OS	Median	All	0.281	0.812	.007	9	view →
BLCA	DFS	Median	II,III,IV	1.000	0.499	.026	6	view →
ESCA	OS	Median	II,III,IV	0.321	0.685	.035	6	view →
COAD	OS	Median	III,IV	0.168	0.692	.043	3	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PWWP3A–LUSC (OS)

Open the LUSC breakdown →