PWWP3A

Across TCGA pan-cancer cohorts, PWWP3A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PWWP3A data layer compared with 28 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PWWP3A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PWWP3A expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

PDAC, HNSC, and UCEC are the cancer types where PWWP3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.170	0.775	.006	30	view →
HNSC	DFS	Quartile	III,IV	1.000	0.374	.008	29	view →
UCEC	DFS	Median	III,IV	0.498	1.000	.013	12	view →
LUAD	DFS	Median	III,IV	0.532	0.995	.010	6	view →
GBM	OS	Quartile	All	0.649	0.271	.019	4	view →
LSCC	OS	Tertile	All	1.000	0.841	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PWWP3A–PDAC (DFS)

Open the PDAC breakdown →