PWWP3A

Across TCGA pan-cancer cohorts, PWWP3A mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PWWP3A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PWWP3A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PWWP3A is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and CCRCC are the cancer types where PWWP3A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PWWP3A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−0.567	<.001	8	view →
LSCC	Male	All	−0.309	<.001	8	view →
CCRCC	Male	All	+0.332	<.001	6	view →
PDAC	All	All	−0.400	.003	4	view →
HNSC	All	IV	−0.398	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PWWP3A–LUAD

Open the LUAD breakdown →