PWWP3A

Across TCGA patient cohorts, PWWP3A mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PWWP3A-associated genes across cancer lineages are STAT3_pY705, Di-Ras3, and BRD4. Each is linked with PWWP3A in more than 1 cancer types. Because this analysis shows association rather than direction, both PWWP3A-to-partner and partner-to-PWWP3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by PWWP3A-low versus PWWP3A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP3A→partner) and Y-score (partner→PWWP3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	STAT3_pY705 →	-0.306	-2.991	.023	.036	3	2
UCEC	Di-Ras3 →	-0.128	-2.308	.021	.033	3	2
COAD	BRD4 →	+0.340	+2.821	.044	.035	3	1
UCEC	JNK2 →	+0.207	+1.765	.005	.014	3	1
UCEC	Ku80 →	+0.259	+1.778	.003	.008	3	1
UCEC	P-Cadherin →	-0.108	-1.401	.045	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

STAT3_pY705 by PWWP3A expression — COAD

Explore this box plot interactively →