PWWP3A

Across TCGA cell cohorts, PWWP3A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,900 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PWWP3A-associated GO terms across cancer lineages are Subtelomeric heterochromatin formation, Positive regulation of double-strand break repair, and Positive regulation of DNA metabolic process. Each is linked with PWWP3A in more than 16 cancer types. Because this analysis shows association rather than direction, both PWWP3A-to-partner and partner-to-PWWP3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Subtelomeric heterochromatin formation grouped by PWWP3A-low versus PWWP3A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP3A→partner) and Y-score (partner→PWWP3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Subtelomeric heterochromatin formation →	+0.136	+0.874	<.001	<.001	3	17
STOMACH	Positive regulation of double-strand break repair →	+0.079	+0.977	.006	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA metabolic process →	+0.070	+1.155	<.001	<.001	3	16
PANCREAS	Regulation of double-strand break repair →	+0.068	+0.972	<.001	<.001	3	16
OESOPHAGUS	Negative regulation of calcium ion export across plasma membrane →	+0.104	+1.068	.002	.007	3	15
PANCREAS	Microtubule nucleation →	+0.111	+0.918	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,900 associations by consensus.

Subtelomeric heterochromatin formation by PWWP3A expression — BONE

Explore this box plot interactively →