PWWP3A

Across TCGA cell cohorts, PWWP3A mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PWWP3A-associated genes across cancer lineages are OR11H2, CCL18, and CFHR2. Each is linked with PWWP3A in more than 1 cancer types. Because this analysis shows association rather than direction, both PWWP3A-to-partner and partner-to-PWWP3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H2 grouped by PWWP3A-low versus PWWP3A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP3A→partner) and Y-score (partner→PWWP3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR11H2 →	+0.048	+3.786	<.001	.002	3	2
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CFHR2 →	+0.057	+5.022	<.001	.002	3	1
SKIN	C3orf56 →	+0.006	+4.977	<.001	.007	3	1
BLOOD_Leukemia	SLC5A4 →	+0.310	+4.471	<.001	.001	3	1
BLOOD_Leukemia	PHOX2B →	+0.019	+4.687	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

OR11H2 by PWWP3A expression — BLOOD_Leukemia

Explore this box plot interactively →