PWWP3A

Across TCGA cell cohorts, PWWP3A mutation is significantly associated with the mutation status of many other genes, with 2,996 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PWWP3A-associated genes across cancer lineages are SLC25A2, NUP62, and HCFC1. Each is linked with PWWP3A in more than 2 cancer types. Because this analysis shows association rather than direction, both PWWP3A-to-partner and partner-to-PWWP3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A2 grouped by PWWP3A-low versus PWWP3A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP3A→partner) and Y-score (partner→PWWP3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC25A2 →	+4.392	+4.392	.009	.009	1	3
BLOOD_Lymphoma	NUP62 →	+5.247	+4.429	.005	.005	1	3
CNS	HCFC1 →	+3.862	+4.347	.001	.001	1	3
BLOOD_Lymphoma	ARHGEF10 →	+4.247	+5.523	<.001	<.001	1	3
STOMACH	CCDC136 →	+4.807	+4.807	.008	.008	1	3
BLOOD_Leukemia	CCDC88A →	+3.247	+3.050	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,996 associations by consensus.

SLC25A2 by PWWP3A expression — SKIN

Explore this box plot interactively →