PWRN4

Across TCGA pan-cancer cohorts, PWRN4 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated PWRN4 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher PWRN4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PWRN4 expression acts as an unfavorable survival marker, although some lineages such as ACC and KIRP show a favorable association.

KICH, CESC, and LUSC are the cancer types where PWRN4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.053	0.918	<.001	144	view →
CESC	OS	Tertile	All	0.571	0.880	.001	102	view →
LUSC	DFS	Tertile	II,III,IV	0.358	0.621	.020	63	view →
LIHC	OS	Tertile	II,III,IV	0.185	0.464	.006	54	view →
BRCA	DFS	Tertile	III,IV	0.445	0.885	<.001	45	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	27	view →
READ	OS	Tertile	IV	0.334	0.918	<.001	27	view →
COAD	OS	Tertile	III,IV	0.114	0.570	.016	18	view →
MESO	OS	Tertile	IV	0.036	0.602	<.001	18	view →
ACC	OS	Tertile	IV	0.832	0.407	.027	12	view →
KIRP	OS	Tertile	All	0.966	0.651	.043	9	view →
UCS	DFS	Tertile	III,IV	0.513	0.165	.028	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

PWRN4–KICH (DFS)

Open the KICH breakdown →