PWRN3

Across TCGA pan-cancer cohorts, PWRN3 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated PWRN3 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher PWRN3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PWRN3 expression acts as an unfavorable survival marker, although some lineages such as UCS and OV show a favorable association.

UCS, MESO, and OV are the cancer types where PWRN3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	All	0.776	0.229	<.001	126	view →
MESO	OS	Tertile	II,III,IV	0.330	0.584	.004	45	view →
OV	OS	Tertile	III,IV	0.894	0.814	.012	32	view →
LUAD	DFS	Tertile	II,III,IV	0.476	0.225	.013	30	view →
COAD	OS	Tertile	All	0.251	0.583	<.001	27	view →
UVM	DFS	Tertile	All	0.079	0.746	<.001	27	view →
PAAD	DFS	Median	III,IV	0.893	0.470	.024	19	view →
DLBC	DFS	Tertile	III,IV	0.137	0.790	<.001	18	view →
KIRP	DFS	Tertile	All	0.978	0.873	.001	14	view →
KIRC	DFS	Tertile	IV	0.409	0.677	.037	6	view →
BLCA	OS	Quartile	All	0.812	0.694	.030	6	view →
HNSC	DFS	Tertile	III,IV	0.126	0.352	.049	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

PWRN3–UCS (OS)

Open the UCS breakdown →