PWRN2

Across TCGA pan-cancer cohorts, PWRN2 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated PWRN2 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher PWRN2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PWRN2 expression acts as an unfavorable survival marker, although some lineages such as UCS and ESCA show a favorable association.

UCS, KIRC, and ESCA are the cancer types where PWRN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	All	1.000	0.202	.002	102	view →
KIRC	DFS	Tertile	IV	0.316	0.702	.001	95	view →
ESCA	DFS	Quartile	III,IV	0.846	0.251	.002	64	view →
MESO	OS	Tertile	III,IV	0.036	0.563	<.001	63	view →
READ	OS	Tertile	All	0.545	0.922	<.001	54	view →
BRCA	OS	Tertile	III,IV	0.132	0.554	.001	36	view →
THCA	DFS	Tertile	II,III,IV	0.636	0.906	.006	24	view →
LUAD	DFS	Tertile	III,IV	0.217	0.678	.011	18	view →
KIRP	DFS	Tertile	III,IV	0.209	0.725	.002	18	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	16	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	9	view →
LIHC	DFS	Tertile	All	0.177	0.536	.015	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

PWRN2–UCS (DFS)

Open the UCS breakdown →