PWP1

Across TCGA pan-cancer cohorts, PWP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PWP1 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PWP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PWP1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

CCRCC, COAD, and LUAD are the cancer types where PWP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.727	0.943	<.001	91	view →
COAD	DFS	Tertile	II,III,IV	0.891	1.000	.015	48	view →
LUAD	DFS	Median	III,IV	0.797	0.222	<.001	29	view →
GBM	OS	Quartile	All	0.562	0.269	.005	15	view →
UCEC	OS	Median	II,III,IV	1.000	0.675	.030	12	view →
LSCC	DFS	Tertile	II,III,IV	0.916	0.215	.006	8	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PWP1–CCRCC (OS)

Open the CCRCC breakdown →