PWP1

Across TCGA patient cohorts, PWP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,202 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PWP1-associated proteins across cancer lineages are MAP3K8_S141, SCYL2, and MKI67. Each is linked with PWP1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PWP1-to-partner and partner-to-PWP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PWP1 versus MAP3K8_S141 in LSCC, with a Pearson correlation of -0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PWP1→partner) and Y-score (partner→PWP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP3K8_S141 →	-0.515	-0.485	<.001	<.001	3	8
BRCA	SCYL2 →	+0.270	+0.357	<.001	<.001	3	6
LUAD	MKI67 →	+0.556	+0.326	.001	<.001	3	5
OV	MTREX →	+0.340	+0.446	<.001	.001	3	5
LSCC	NAA25 →	+0.308	+0.519	<.001	<.001	3	5
LSCC	NCAPG →	+0.505	+0.485	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,202 associations by consensus.

PWP1 vs MAP3K8_S141 — LSCC

Explore this scatter interactively →