PWP1

Across TCGA patient cohorts, PWP1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PWP1-associated genes across cancer lineages are ATM, eEF2, and EGFR_pY1068. Each is linked with PWP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PWP1-to-partner and partner-to-PWP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PWP1-low versus PWP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWP1→partner) and Y-score (partner→PWP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.478	-1.807	.010	.027	3	2
UCEC	eEF2 →	+0.396	+2.999	.007	.035	3	1
UCEC	EGFR_pY1068 →	-0.265	-2.321	.010	.006	3	1
UCEC	A-Raf_pS299 →	-0.104	-3.321	.035	.010	3	1
UCEC	ERK2 →	+0.177	+3.169	.026	.018	3	1
UCEC	GATA6 →	-0.158	-2.000	.013	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ATM by PWP1 expression — UCEC

Explore this box plot interactively →