PWP1

Across TCGA cell cohorts, PWP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,827 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PWP1-associated GO terms across cancer lineages are Regulation of mitotic sister chromatid separation, Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and DNA replication initiation. Each is linked with PWP1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PWP1-to-partner and partner-to-PWP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic sister chromatid separation grouped by PWP1-low versus PWP1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PWP1→partner) and Y-score (partner→PWP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of mitotic sister chromatid separation →	+0.121	+0.572	.004	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.166	+0.916	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.146	+0.796	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	rRNA 5'-end processing →	+0.128	+0.720	.001	.001	2	14
UPPER_AERODIGESTIVE_TRACT	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.128	+0.720	.001	.001	2	14
UPPER_AERODIGESTIVE_TRACT	Maturation of SSU-rRNA →	+0.116	+0.687	.004	.003	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,827 associations by consensus.

Regulation of mitotic sister chromatid separation by PWP1 expression — OESOPHAGUS

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