Across TCGA cell cohorts, PVALEF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,042 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PVALEF-associated GO terms across cancer lineages are Negative regulation of mRNA metabolic process, Negative regulation of transcription elongation by RNA polymerase II, and Constitutive heterochromatin formation. Each is linked with PVALEF in more than 13 cancer types. Because this analysis shows association rather than direction, both PVALEF-to-partner and partner-to-PVALEF results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PVALEF→partner) and Y-score (partner→PVALEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of mRNA metabolic process →	+0.091	+0.103	<.001	.008	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of transcription elongation by RNA polymerase II →	+0.119	+0.028	<.001	.004	3	13
LUNG_SCLC	Constitutive heterochromatin formation →	+0.114	+0.181	<.001	.002	3	13
STOMACH	Positive regulation of double-strand break repair →	+0.090	+0.179	.001	.007	3	13
OVARY	Heterochromatin formation →	+0.072	+0.073	<.001	.003	3	13
BONE	Subtelomeric heterochromatin formation →	+0.119	+0.086	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,042 associations by consensus.

Exploration

PVALEF survival (RNA) · tumor vs normal (RNA) · all PVALEF data types