PVALB

Across TCGA patient cohorts, PVALB protein abundance is significantly associated with the RNA expression of many other genes, with 8,439 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PVALB-associated genes across cancer lineages are PRKCB, CHRDL1, and MYH1. Each is linked with PVALB in more than 3 cancer types. Because this analysis shows association rather than direction, both PVALB-to-partner and partner-to-PVALB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PVALB versus PRKCB in GBM, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PVALB→partner) and Y-score (partner→PVALB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRKCB →	+0.880	+0.563	<.001	.001	3	4
UCEC	CHRDL1 →	+1.727	+0.721	.001	.002	3	3
HNSC	MYH1 →	+2.847	+0.733	<.001	<.001	3	3
UCEC	PLPP2 →	-1.332	-0.674	<.001	<.001	3	3
UCEC	LRFN5 →	+1.207	+0.732	<.001	.002	3	3
GBM	P2RY12 →	+0.849	+0.690	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,439 associations by consensus.

PVALB vs PRKCB — GBM

Explore this scatter interactively →