PUSL1

Across TCGA patient cohorts, PUSL1 mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUSL1-associated genes across cancer lineages are RNA5SP416, RNU6-1213P, and RNA5SP412. Each is linked with PUSL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUSL1-to-partner and partner-to-PUSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP416 grouped by PUSL1-low versus PUSL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUSL1→partner) and Y-score (partner→PUSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP416 →	+1.282	+4.224	<.001	.001	3	2
UCEC	RNU6-1213P →	+0.464	+4.877	<.001	.003	3	2
UCEC	RNA5SP412 →	+1.713	+3.967	<.001	.001	3	2
BLCA	RNU6-1118P →	+0.488	+6.040	<.001	.001	3	2
BLCA	TRIM42 →	+0.029	+5.495	<.001	<.001	3	1
BLCA	RNU6-626P →	+0.316	+4.788	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

RNA5SP416 by PUSL1 expression — UCEC

Explore this box plot interactively →