PUS7L

Across TCGA pan-cancer cohorts, PUS7L Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PUS7L data layer compared with 29 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PUS7L Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PUS7L expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, BRCA, and LUSC are the cancer types where PUS7L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.868	0.629	.005	30	view →
BRCA	OS	Median	All	0.148	0.578	.013	16	view →
LUSC	OS	Median	II,III,IV	0.250	0.778	.023	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PUS7L–UCEC (DFS)

Open the UCEC breakdown →