PUS7

Across TCGA pan-cancer cohorts, PUS7 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PUS7’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PUS7 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PUS7 is over-expressed in tumor.

CCRCC, COAD, and HNSC are the cancer types where PUS7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PUS7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.638	<.001	12	view →
COAD	Male	II,III,IV	+0.753	<.001	11	view →
HNSC	All	IV	+0.661	<.001	11	view →
LSCC	Male	II,III,IV	+0.988	<.001	9	view →
LUAD	Male	All	+0.540	<.001	9	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PUS7–CCRCC

Open the CCRCC breakdown →