PUS7

Across TCGA patient cohorts, PUS7 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUS7-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and INPP4B. Each is linked with PUS7 in more than 2 cancer types. Because this analysis shows association rather than direction, both PUS7-to-partner and partner-to-PUS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PUS7-low versus PUS7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS7→partner) and Y-score (partner→PUS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.498	+1.894	.032	.030	3	3
UCEC	ATM →	-0.588	-2.446	<.001	.018	3	2
UCEC	INPP4B →	-0.298	-1.571	.018	.036	3	1
UCEC	JNK2 →	+0.220	+2.000	.004	.010	3	1
UCEC	Ku80 →	+0.191	+1.598	.039	.022	3	1
UCEC	MEK1 →	+0.457	+2.415	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Caspase-7-cleavedD198 by PUS7 expression — UCEC

Explore this box plot interactively →