PUS10

Across TCGA patient cohorts, PUS10 protein abundance is significantly associated with the RNA expression of many other genes, with 5,751 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PUS10-associated genes across cancer lineages are MICU1, STEAP3, and NIP7. Each is linked with PUS10 in more than 3 cancer types. Because this analysis shows association rather than direction, both PUS10-to-partner and partner-to-PUS10 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PUS10 versus MICU1 in GBM, with a Pearson correlation of -0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS10→partner) and Y-score (partner→PUS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MICU1 →	-0.435	-0.379	<.001	<.001	3	3
BRCA	STEAP3 →	+1.030	+0.318	<.001	<.001	3	3
BRCA	NIP7 →	+0.406	+0.272	.005	.004	2	4
LSCC	PEX13 →	+0.381	+0.297	.003	<.001	3	3
CCRCC	NFATC4 →	-0.830	-0.254	<.001	.002	3	3
UCEC	DKK1 →	-2.267	-0.280	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,751 associations by consensus.

PUS10 vs MICU1 — GBM

Explore this scatter interactively →