PUS10

Across TCGA patient cohorts, PUS10 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUS10-associated genes across cancer lineages are PDCD4, Rab25, and C-Raf. Each is linked with PUS10 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUS10-to-partner and partner-to-PUS10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by PUS10-low versus PUS10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS10→partner) and Y-score (partner→PUS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.523	-1.584	.004	.036	3	2
UCEC	Rab25 →	-0.287	-3.169	.027	.018	3	2
UCEC	C-Raf →	+0.200	+2.000	<.001	.030	3	2
UCEC	eIF4G →	+0.292	+3.169	.016	.018	3	1
UCEC	A-Raf_pS299 →	-0.154	-2.584	<.001	.010	3	1
UCEC	FoxM1 →	+0.286	+2.502	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

PDCD4 by PUS10 expression — UCEC

Explore this box plot interactively →