PURG

Across TCGA pan-cancer cohorts, PURG Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PURG data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PURG Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PURG expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, ESCA, and LUAD are the cancer types where PURG Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.629	.020	20	view →
ESCA	OS	Median	II,III,IV	0.130	0.703	<.001	18	view →
LUAD	OS	Median	All	0.331	0.688	.001	15	view →
HNSC	DFS	Median	IV	1.000	0.307	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PURG–UCEC (DFS)

Open the UCEC breakdown →