PURG

Across TCGA patient cohorts, PURG mutation is significantly associated with the RNA expression of many other genes, with 1,818 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PURG-associated genes across cancer lineages are RNA5SP264, SPTLC1P3, and MIR6894. Each is linked with PURG in more than 1 cancer types. Because this analysis shows association rather than direction, both PURG-to-partner and partner-to-PURG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP264 grouped by PURG-low versus PURG-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PURG→partner) and Y-score (partner→PURG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP264 →	+0.232	+5.339	<.001	.003	3	2
HNSC	SPTLC1P3 →	+0.697	+4.594	<.001	.004	3	2
UCEC	MIR6894 →	+0.625	+2.496	<.001	<.001	3	2
UCEC	PAXIP1 →	+0.508	+2.309	<.001	.004	3	2
UCEC	PDSS2 →	+0.543	+3.000	.001	.001	3	2
UCEC	PDZD8 →	+1.009	+2.513	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,818 associations by consensus.

RNA5SP264 by PURG expression — HNSC

Explore this box plot interactively →